HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	15356202, 12888622
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 293
+	Hs
		496654 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP7_HUMAN (33-288): 3.89e-113: 330: 38.28
+	Hs
		496496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP3_HUMAN (37-289): 1.09e-110: 323: 41.90
+	Hs
		496497 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP2_HUMAN (37-291): 7.54e-100: 301: 29.12
+	Hs
		497029 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP8_HUMAN (5-289): 3.37e-98: 298: 30.20
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (11-291): 1.32e-98: 296: 23.89
+	Hs
		496414 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASPE_HUMAN (33-288): 3.86e-71: 221: 27.31
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (37-289): 1.09e-110: 323: 41.90