HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AP1S2 (P56377)
AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)
Gene: AP1S2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 157
+	Hs
		497365 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP3S1_HUMAN (1-143): 5.8e-49: 157: 36.91
+	Hs
		497548 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1M1_HUMAN (2-153): 2.63e-43: 149: 19.23
+	Hs
		497422 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Hs
		496722 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPZ1_HUMAN (1-154): 4.68e-41: 137: 19.87
+	Hs
		496627 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2S1_HUMAN (1-141): 2.21e-41: 136: 46.10
+	Rn
		581982 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2M1_RAT (1-153): 7.95e-41: 143: 16.23
+	Rn
		94205 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AP2M1_RAT (1-153): 7.95e-41: 143: 16.23
+	Mm
		498140 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP3S1_MOUSE (1-143): 5.8e-49: 157: 36.91
+	Mm
		498008 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2M1_MOUSE (1-153): 7.95e-41: 143: 16.23
+	Hs
		654028 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23
+	Mm
		592762 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		AP2S1_MOUSE (1-141): 2.21e-41: 136: 46.10
+	Mm
		649203 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		AP2S1_MOUSE (1-141): 2.21e-41: 136: 46.10
+	Dm
		248311 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		O62530_DROME (1-154): 1.13e-40: 142: 17.53
+	Hs
		203244 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2M1_HUMAN (1-153): 7.95e-41: 143: 16.23