HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0030426 - growth cone GO:0043005 - neuron projection and 1 others more... GO:0043025 - neuronal cell body
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 192
+	Hs
		496789 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		496691 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		496717 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436133 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Mm
		498009 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RHOG_MOUSE (1-192): 2.62e-78: 233: 69.79
+	Mm
		498148 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		RHOA_MOUSE (5-192): 9.79e-77: 229: 54.79
+	Hs
		653946 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		297823 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Ce
		136793 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		RAC1_CAEEL (1-192): 1.53e-82: 244: 81.25
+	Hs
		297812 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		297840 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		297819 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		297827 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		297820 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Ce
		104464 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		G5EBV3_CAEEL (2-192): 2.34e-77: 231: 63.87
+	Hs
		297809 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Ce
		136794 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		CDC42_CAEEL (1-192): 3.66e-75: 225: 67.71
+	Hs
		894572 MUC12_HUMAN (15-752): 1.81e-12: 73.5: 8.54		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75