HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 406
+	Hs
		91440 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E7EQG2_HUMAN (3-359): 0: 530: 90.20
+	Hs
		497009 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		496251 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		497386 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Mm
		496125 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		IF4A2_MOUSE (4-406): 4.47e-158: 453: 90.32
+	Mm
		498030 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX17_MOUSE (2-406): 1.38e-137: 409: 29.33
+	Mm
		498084 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BTS0_MOUSE (10-406): 4.82e-138: 409: 29.88
+	Hs
		496341 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		757612 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Dm
		1367483 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		IF4A3_DROME (9-406): 2.49e-132: 387: 68.09