HitPredict

Interactor 1: IRGM (A1A4Y4)
Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47)
Gene: IRGM

Interactor 2: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

The method score is based on:

Property	Details
Experiments	25891078, 36221902
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0006952 - defense response GO:0019901 - protein kinase binding and 8 others more... GO:0032689 - negative regulation of type II interferon production GO:0042742 - defense response to bacterium GO:0045087 - innate immune response GO:0050700 - CARD domain binding GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0071222 - cellular response to lipopolysaccharide GO:1901526 - positive regulation of mitophagy GO:1904417 - positive regulation of xenophagy
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	181
Hs

1	1040

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024