HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	12963086, 32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0005886 - plasma membrane and 2 others more... GO:0019901 - protein kinase binding GO:0030424 - axon
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 594
+	Hs
		2825 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		A0A0D9SG72_HUMAN (15-594): 0: 662: 100.00
+	Rn
		581963 TAU_RAT (1-758): 4.86e-75: 260: 71.47		STXB1_RAT (1-594): 0: 680: 100.00
+	Rn
		94186 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		STXB1_RAT (1-594): 0: 680: 100.00
+	Mm
		139535 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Mm
		139538 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Hs
		497652 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VPS45_HUMAN (12-582): 5.03e-154: 456: 17.81
+	Hs
		497410 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		VP33A_HUMAN (6-584): 2.96e-136: 411: 16.09