HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	32812023, 26269332, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 463
+	Mm
		497970 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00
+	Hs
		496596 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NOVA1_HUMAN (1-460): 1.64e-77: 252: 19.31
+	Hs
		497805 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NOVA2_HUMAN (12-460): 4.99e-67: 224: 18.13
+	Hs
		497065 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21
+	Hs
		497393 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		497064 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15
+	Hs
		497692 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IF2B1_HUMAN (175-462): 1.88e-09: 62: 11.57
+	Hs
		497407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FUBP1_HUMAN (300-460): 2.19e-09: 61.6: 19.64
+	Hs
		128005 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IF2B3_HUMAN (272-463): 9e-09: 59.7: 14.57
+	Mm
		498053 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PCBP2_MOUSE (23-147): 1.3e-12: 70.9: 21.09
+	Mm
		497959 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PCBP1_MOUSE (23-127): 3.42e-12: 69.7: 23.15
+	Mm
		497957 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PCBP3_MOUSE (2-114): 6.62e-11: 65.8: 16.24
+	Hs
		653982 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15
+	Hs
		1056915 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		1056922 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		FUBP1_HUMAN (300-460): 2.19e-09: 61.6: 19.64