HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	36931259, 32812023, 35063084, 26269332, 28575131
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048167 - regulation of synaptic plasticity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 247
+	Hs
		496737 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		496898 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Rn
		581965 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433E_RAT (1-244): 2.02e-141: 398: 63.53
+	Rn
		94188 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433E_RAT (1-244): 2.02e-141: 398: 63.53
+	Rn
		581964 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433G_RAT (1-247): 3.15e-139: 392: 100.00
+	Rn
		94187 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433G_RAT (1-247): 3.15e-139: 392: 100.00
+	Mm
		497973 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		497971 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433G_MOUSE (1-247): 3.15e-139: 392: 100.00
+	Mm
		498003 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		496415 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		496795 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		496356 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		496416 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Rn
		581974 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433Z_RAT (2-245): 8.46e-109: 315: 74.59
+	Rn
		94197 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433Z_RAT (2-245): 8.46e-109: 315: 74.59
+	Rn
		581977 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433T_RAT (2-245): 3e-105: 306: 70.73
+	Rn
		94200 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433T_RAT (2-245): 3e-105: 306: 70.73
+	Mm
		497995 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Mm
		498123 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Mm
		250865 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433S_MOUSE (2-236): 1.38e-95: 281: 65.96