HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	16262633, 21489990, 35063084
Identification Methods	enzymatic study, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010288 - response to lead ion and 1 others more... GO:0043197 - dendritic spine
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 330
+	Hs
		496456 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Hs
		496730 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1B_HUMAN (1-330): 0: 568: 87.88
+	Mm
		497972 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1A_MOUSE (1-330): 0: 614: 99.70
+	Mm
		497993 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1G_MOUSE (1-330): 0: 579: 90.66
+	Hs
		496758 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP2AB_HUMAN (8-302): 1.41e-176: 492: 47.97
+	Hs
		496809 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30
+	Hs
		653952 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PP1A_HUMAN (1-330): 0: 614: 100.00
+	Mm
		649202 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		PP1A_MOUSE (1-330): 0: 614: 99.70
+	Hs
		905894 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP1A_HUMAN (1-330): 0: 614: 100.00
+	Mm
		906349 TARA_MOUSE (3-751): 2.63e-09: 63.2: 8.51		PP1A_MOUSE (1-330): 0: 614: 99.70
+	Dm
		54320 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		Q8T0U6_DROME (19-326): 0: 537: 84.42
+	Dm
		113980 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		PP1B_DROME (6-326): 0: 551: 83.49
+	Hs
		930846 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30
+	Bt
		664292 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		PP2AA_BOVIN (8-302): 3.14e-176: 492: 47.30