HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	32812023, 35063084, 26269332
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 406
+	Hs
		496732 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		496509 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		496448 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Dm
		1359411 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9V405_DROME (7-399): 9.79e-122: 360: 41.73
+	Hs
		496752 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64