HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	29659825, 29382714, 35063084, 26269332, 28575131
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding and 1 others more... GO:0034605 - cellular response to heat
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 255
+	Rn
		581965 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433E_RAT (1-255): 4.87e-154: 430: 100.00
+	Rn
		94188 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433E_RAT (1-255): 4.87e-154: 430: 100.00
+	Mm
		497973 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909712 OTOG_HUMAN (8-580): 2.66e-24: 112: 12.48		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		297821 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00