HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PP2AB (P62714)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
Gene: PPP2CB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	7616230, 16262633
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010288 - response to lead ion GO:0010629 - negative regulation of gene expression
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 309
+	Hs
		496809 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP2AA_HUMAN (1-309): 0: 533: 97.41
+	Hs
		496456 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1G_HUMAN (7-306): 0: 510: 46.60
+	Hs
		496729 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PP1A_HUMAN (5-296): 0: 508: 47.18
+	Mm
		497999 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP2AA_MOUSE (1-309): 0: 532: 97.41
+	Mm
		497993 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1G_MOUSE (7-306): 0: 510: 46.60
+	Mm
		497972 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PP1A_MOUSE (5-296): 0: 509: 47.51
+	Hs
		930846 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP2AA_HUMAN (1-309): 0: 533: 97.41
+	Hs
		653952 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PP1A_HUMAN (5-296): 0: 508: 47.18
+	Mm
		649202 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		PP1A_MOUSE (5-296): 0: 509: 47.51
+	Hs
		905894 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		PP1A_HUMAN (5-296): 0: 508: 47.18
+	Bt
		664292 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		PP2AA_BOVIN (1-309): 0: 533: 97.41
+	Mm
		906349 TARA_MOUSE (3-751): 2.63e-09: 63.2: 8.51		PP1A_MOUSE (5-296): 0: 509: 47.51