HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 340
+	Hs
		496777 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		921574 SPEG_HUMAN (183-564): 6e-23: 107: 16.71		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Mm
		497983 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNB5_MOUSE (129-340): 1.22e-45: 161: 21.92
+	Hs
		496503 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		LIS1_HUMAN (259-340): 1.35e-18: 87.8: 23.17
+	Hs
		152663 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5B_HUMAN (71-340): 2.74e-83: 257: 25.18
+	Hs
		196948 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85
+	Hs
		653951 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		1056932 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SNR40_HUMAN (130-340): 2.9e-59: 196: 24.30
+	Hs
		152622 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Mm
		903669 KMT2C_MOUSE (228-587): 6.06e-09: 61.9: 16.84		WDR5_MOUSE (4-211): 4.16e-56: 187: 20.93
+	Hs
		903374 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Dm
		1370295 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		POC1_DROME (180-340): 1.63e-13: 72.8: 25.00