HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 394
+	Hs
		497152 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAS1_HUMAN (11-394): 6.95e-170: 503: 95.05
+	Hs
		391314 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		496793 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		444653 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		450973 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		496575 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		496380 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		325959 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNA14_HUMAN (11-394): 4.75e-146: 420: 38.28
+	Hs
		496266 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Rn
		581959 TAU_RAT (1-758): 4.86e-75: 260: 71.47		GNAO_RAT (1-394): 1.17e-151: 434: 40.91
+	Mm
		70618 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAI1_MOUSE (1-394): 5.37e-158: 450: 39.09
+	Rn
		94182 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		GNAO_RAT (1-394): 1.17e-151: 434: 40.91
+	Mm
		444631 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAI2_MOUSE (1-394): 7.23e-158: 449: 38.83
+	Mm
		497926 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAQ_MOUSE (11-394): 5.78e-151: 432: 38.02
+	Mm
		497925 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNA11_MOUSE (11-394): 1.81e-147: 423: 38.80
+	Mm
		250846 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GNAZ_MOUSE (1-393): 1.9e-142: 410: 36.64