HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.763

Property	Details
Experiments	19138662, 19647741, 27548710, 23962087, 17317006, 10840038, 15650334, 29659825, 12551948, 35063084, 26269332, 28575131
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, molecular sieving, comigration in non denaturing gel electrophoresis, anti bait coimmunoprecipitation, cross-linking study, biochemical, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 245
+	Hs
		496737 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		496356 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		496415 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Rn
		581974 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433Z_RAT (1-245): 3.48e-145: 407: 99.59
+	Rn
		94197 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433Z_RAT (1-245): 3.48e-145: 407: 99.59
+	Rn
		581965 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433E_RAT (2-241): 9.9e-144: 403: 68.18
+	Rn
		94188 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433E_RAT (2-241): 9.9e-144: 403: 68.18
+	Rn
		581977 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433T_RAT (1-245): 8.98e-140: 393: 79.18
+	Rn
		94200 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433T_RAT (1-245): 8.98e-140: 393: 79.18
+	Mm
		497995 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Mm
		497973 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		496727 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		496898 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Mm
		498123 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433B_MOUSE (1-242): 3.77e-128: 364: 87.19
+	Hs
		496416 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Rn
		581964 TAU_RAT (1-758): 4.86e-75: 260: 71.47		1433G_RAT (1-240): 2.37e-108: 314: 74.59
+	Rn
		94187 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		1433G_RAT (1-240): 2.37e-108: 314: 74.59
+	Mm
		497971 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Mm
		498003 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Mm
		250865 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		1433S_MOUSE (1-232): 7.92e-104: 302: 73.08