HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TBA1B (P68363)
Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]
Gene: TUBA1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	16687396, 36634849, 24905733, 35063084
Identification Methods	pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005874 - microtubule GO:0015630 - microtubule cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 451
+	Hs
		497515 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBA1C_HUMAN (1-451): 0: 728: 98.00
+	Hs
		496818 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBA4A_HUMAN (1-450): 0: 719: 96.44
+	Hs
		497220 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBA1A_HUMAN (1-440): 0: 715: 99.55
+	Hs
		497683 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBA8_HUMAN (1-440): 0: 701: 90.68
+	Hs
		427983 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.23
+	Hs
		496819 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.96
+	Rn
		582020 TAU_RAT (1-758): 4.86e-75: 260: 71.47		TBA1B_RAT (1-440): 0: 717: 100.00
+	Rn
		94246 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		TBA1B_RAT (1-440): 0: 717: 100.00
+	Mm
		399082 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TBA1B_MOUSE (1-440): 0: 717: 100.00
+	Mm
		498002 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TBA1A_MOUSE (1-440): 0: 715: 99.55
+	Mm
		498012 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TBB5_MOUSE (1-439): 0: 699: 41.23
+	Hs
		653957 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		TBA1B_HUMAN (1-440): 0: 717: 100.00
+	Hs
		503294 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		TBA1A_HUMAN (1-440): 0: 715: 99.55
+	Mm
		649204 MAP4_MOUSE (10-742): 3.04e-29: 127: 18.63		TBA1A_MOUSE (1-440): 0: 715: 99.55
+	Hs
		92120 NACAM_HUMAN (203-750): 1.03e-12: 74.3: 9.75		TBA1A_HUMAN (1-440): 0: 715: 99.55