HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	15882073, 35063084
Identification Methods	enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006974 - DNA damage response GO:0051879 - Hsp90 protein binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 391
+	Hs
		497319 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47
+	Hs
		496330 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74
+	Hs
		496572 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12
+	Rn
		94143 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		GSK3B_RAT (10-390): 1.3e-116: 347: 26.60
+	Mm
		498164 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		GSK3B_MOUSE (39-389): 4.72e-112: 335: 29.12
+	Hs
		934167 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		297825 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		653936 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12
+	Hs
		92118 NACAM_HUMAN (203-750): 1.03e-12: 74.3: 9.75		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		554284 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12
+	Bt
		61644 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		A6H7A9_BOVIN (39-389): 7.49e-111: 333: 28.80