HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	23197718, 28826672
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 688
+	Hs
		497472 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22
+	Mm
		222342 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SRPK2_MOUSE (12-688): 7.17e-124: 385: 89.87
+	Mm
		251042 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SRPK1_MOUSE (27-688): 7.22e-123: 381: 52.42
+	Hs
		496330 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83
+	Hs
		497071 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A1_HUMAN (2-359): 1.19e-76: 262: 14.13
+	Hs
		270366 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52
+	Hs
		653958 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66
+	Hs
		942660 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66
+	Hs
		497376 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DYRK2_HUMAN (51-234): 1.48e-62: 221: 29.35
+	Hs
		1057021 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		KS6A6_HUMAN (2-362): 5.53e-77: 263: 15.92
+	Sp
		194038 YFHH_SCHPO (5-755): 4.88e-12: 72: 8.72		DSK1_SCHPO (437-686): 7.4e-74: 250: 44.40
+	Ce
		246633 O61201_CAEEL (56-749): 1.94e-13: 76.6: 10.43		MBK2_CAEEL (63-234): 6.65e-57: 209: 25.58