HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 164
+	Hs
		497104 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		496915 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		496405 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIA1_HUMAN (5-107): 1.38e-18: 83: 21.70
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (1-91): 1.3e-20: 89.2: 25.77
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (1-91): 1.3e-20: 89.2: 25.77
+	Mm
		498010 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00
+	Mm
		497953 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TIA1_MOUSE (5-107): 1.59e-18: 82.6: 21.70
+	Hs
		992772 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1028547 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Dm
		644444 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		SRR55_DROME (11-89): 1.88e-16: 77: 46.84
+	Dm
		60227 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A4V364_DROME (8-84): 4.87e-16: 76.1: 24.10