HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0030673 - axolemma
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2364
+	Rn
		582039 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN2_RAT (2-2318): 0: 636: 61.69
+	Rn
		94264 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN2_RAT (2-2318): 0: 636: 61.69
+	Hs
		497586 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN4_HUMAN (5-2092): 2.42e-155: 540: 52.21
+	Hs
		211474 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN4_HUMAN (53-525): 6.51e-121: 409: 47.58
+	Hs
		496188 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25
+	Rn
		555250 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN1_RAT (266-1626): 2.79e-51: 203: 18.87
+	Rn
		94140 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN1_RAT (266-1626): 2.79e-51: 203: 18.87
+	Hs
		503257 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25
+	Hs
		496176 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DMD_HUMAN (234-2093): 2.37e-21: 105: 9.67
+	Hs
		496988 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		497051 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59
+	Hs
		164558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN2_HUMAN (1661-2338): 1.76e-11: 72.4: 15.10
+	Hs
		503287 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59
+	Dm
		54271 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9I8_DROME (449-2363): 2.09e-09: 65.5: 9.06