HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	24999758, 26269332, 35063084
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 656
+	Hs
		497384 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Mm
		498083 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35
+	Hs
		496444 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		212098 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HTSF1_HUMAN (310-448): 3.35e-28: 122: 20.55
+	Mm
		498044 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		EWS_MOUSE (1-656): 4.67e-42: 163: 94.06
+	Hs
		967173 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		967541 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		726817 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		FUS_HUMAN (55-545): 1.15e-31: 131: 30.35
+	Hs
		118512 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		EYA2_HUMAN (27-278): 1.48e-18: 91.3: 20.16
+	Dm
		435986 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		CO4A1_DROME (378-655): 1.52e-22: 105: 15.68
+	Dm
		1370237 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VMV5_DROME (3-357): 2.61e-15: 82.2: 12.08