HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11104762
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 592
+	Hs
		496492 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCI_HUMAN (1-592): 0: 654: 69.87
+	Hs
		496408 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12
+	Hs
		496407 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		496317 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6B1_HUMAN (227-590): 1.48e-144: 430: 35.60
+	Hs
		116961 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SGK1_HUMAN (199-583): 7.41e-144: 424: 38.36
+	Hs
		496248 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		496604 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47
+	Hs
		554297 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26
+	Hs
		152597 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39
+	Hs
		503261 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06
+	Hs
		496879 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCE_HUMAN (6-196): 1.52e-27: 120: 19.02
+	Hs
		408538 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCB_HUMAN (85-187): 1.04e-21: 101: 27.18
+	Hs
		496245 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63
+	Hs
		397126 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KPCG_HUMAN (116-180): 1.87e-10: 65.9: 36.92
+	Rn
		581978 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KPCB_RAT (101-181): 2.68e-17: 87.6: 30.86
+	Rn
		94201 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KPCB_RAT (101-181): 2.68e-17: 87.6: 30.86
+	Mm
		497997 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KPCG_MOUSE (116-180): 1.79e-10: 65.9: 36.92