HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36634849, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1748
+	Hs
		303740 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ZO3_HUMAN (13-915): 5.56e-135: 446: 38.65
+	Hs
		159141 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		497003 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MPP2_HUMAN (378-806): 1.77e-81: 282: 16.56
+	Hs
		496940 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		497733 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (1108-1664): 5.31e-24: 113: 15.83
+	Mm
		581224 NFH_MOUSE (284-730): 4.84e-16: 84.7: 14.99		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		152667 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		KMT2C_HUMAN (872-1617): 7.83e-14: 79.8: 13.75
+	Mm
		88458 D3Z656_MOUSE (72-555): 1.33e-11: 70.4: 11.56		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Mm
		1143433 SYNJ1_MOUSE (129-637): 3.11e-11: 69.3: 11.20		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Ce
		103468 TTN1_CAEEL (4-632): 3.28e-10: 66.1: 11.61		DLG1_CAEEL (259-528): 1.27e-15: 85: 15.11