HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26269332, 35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 949
+	Hs
		496790 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Rn
		581970 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2B1_RAT (1-949): 0: 944: 81.45
+	Rn
		94193 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AP2B1_RAT (1-949): 0: 944: 81.45
+	Mm
		498136 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2B1_MOUSE (1-949): 0: 944: 81.35
+	Hs
		203223 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP1B1_HUMAN (1-949): 0: 978: 100.00
+	Hs
		926047 MAGL2_HUMAN (1-739): 1.99e-19: 95.9: 10.23		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		203219 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2B1_HUMAN (1-949): 0: 944: 81.45
+	Hs
		321471 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Hs
		302095 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2A2_HUMAN (12-945): 0: 625: 18.33
+	Mm
		497920 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2A1_MOUSE (12-943): 0: 673: 17.97
+	Rn
		577190 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2A2_RAT (12-945): 0: 635: 17.94
+	Rn
		94239 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		Q66HM2_RAT (12-945): 0: 631: 17.92
+	Hs
		212589 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1G1_HUMAN (12-822): 0: 556: 17.29
+	Hs
		496962 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP3B2_HUMAN (6-627): 2.76e-180: 553: 27.47
+	Mm
		498147 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP3B2_MOUSE (6-627): 9.59e-180: 551: 27.47
+	Hs
		203194 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2A1_HUMAN (12-943): 0: 677: 18.58
+	Rn
		1144064 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		Q66HM2_RAT (12-945): 0: 631: 17.92