HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0051260 - protein homooligomerization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1972
+	Hs
		1018956 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		TP53B_HUMAN (1-1972): 0: 766: 100.00
+	Hs
		496529 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41
+	Hs
		496871 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ANK2_HUMAN (3-1685): 1.72e-50: 200: 9.45
+	Rn
		546252 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MAP1B_RAT (10-1590): 3.54e-51: 202: 9.67
+	Rn
		94138 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MAP1B_RAT (10-1590): 3.54e-51: 202: 9.67
+	Hs
		497357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TITIN_HUMAN (6-1527): 2.77e-31: 137: 9.47
+	Rn
		581937 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MAP1A_RAT (6-1480): 1.91e-30: 134: 11.10
+	Rn
		94159 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MAP1A_RAT (6-1480): 1.91e-30: 134: 11.10
+	Hs
		497818 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78
+	Hs
		1303336 MUC4_HUMAN (14-748): 5.84e-22: 104: 10.95		MUC4_HUMAN (32-1771): 6.05e-68: 258: 10.04
+	Hs
		807793 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41
+	Hs
		1056827 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33
+	Dm
		1366600 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VH10_DROME (24-1469): 4.86e-35: 149: 11.78
+	Hs
		1056876 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MICA3_HUMAN (254-923): 1.94e-14: 81.7: 14.49
+	Dm
		54892 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1ZA72_DROME (68-1020): 1.77e-25: 118: 11.26
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (1064-1755): 2.27e-09: 65.1: 8.65
+	Mm
		1351630 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		PCLO_MOUSE (2-1361): 6.91e-09: 63.7: 8.66