HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AP3B2 (Q13367)
AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)
Gene: AP3B2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:1904115 - axon cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1082
+	Mm
		498147 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP3B2_MOUSE (1-1082): 0: 930: 93.90
+	Hs
		496790 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2B1_HUMAN (27-965): 0: 639: 20.79
+	Hs
		496926 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1B1_HUMAN (27-943): 0: 615: 20.76
+	Rn
		581970 TAU_RAT (1-758): 4.86e-75: 260: 71.47		AP2B1_RAT (27-965): 0: 639: 20.79
+	Rn
		94193 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		AP2B1_RAT (27-965): 0: 639: 20.79
+	Mm
		498136 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2B1_MOUSE (27-965): 0: 638: 20.79
+	Hs
		321471 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP2A1_HUMAN (7-956): 9.81e-173: 534: 11.28
+	Hs
		497722 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPG2_HUMAN (8-939): 1.4e-171: 527: 11.28
+	Hs
		497899 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPG1_HUMAN (8-939): 2.26e-171: 527: 11.25
+	Hs
		212589 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		AP1G1_HUMAN (18-818): 3.11e-171: 525: 13.18
+	Mm
		497920 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		AP2A1_MOUSE (7-956): 4.61e-171: 529: 11.38
+	Hs
		926047 MAGL2_HUMAN (1-739): 1.99e-19: 95.9: 10.23		AP2B1_HUMAN (27-965): 0: 639: 20.79
+	Hs
		203219 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2B1_HUMAN (27-965): 0: 639: 20.79
+	Rn
		94239 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		Q66HM2_RAT (11-667): 5.62e-138: 442: 12.23
+	Hs
		203223 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP1B1_HUMAN (27-943): 0: 615: 20.76
+	Hs
		203194 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		AP2A1_HUMAN (7-956): 9.81e-173: 534: 11.28
+	Rn
		1144064 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		Q66HM2_RAT (11-667): 5.62e-138: 442: 12.23
+	Hs
		496624 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COPB_HUMAN (42-641): 8.95e-54: 206: 17.50