HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	20071522, 35244772, 30382094
Identification Methods	affinity chromatography technology, pull down, nuclear magnetic resonance, fluorescence technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 457
+	Hs
		496884 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Rn
		582038 TAU_RAT (1-758): 4.86e-75: 260: 71.47		FKBP4_RAT (1-444): 1.17e-137: 404: 55.16
+	Hs
		496920 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		496417 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		496352 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FKBP2_HUMAN (153-255): 1.29e-23: 98: 27.52
+	Hs
		496785 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Rn
		193483 TAU_RAT (1-758): 4.86e-75: 260: 71.47		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Rn
		94104 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		STIP1_RAT (265-457): 1.25e-22: 102: 18.14