HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PIN1 (Q13526)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)
Gene: PIN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	32812023, 22235112, 10391244, 16365047, 35063084
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck GO:0050808 - synapse organization
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 163
+	Mm
		498150 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PIN1_MOUSE (1-163): 3.37e-83: 243: 95.15
+	Hs
		111612 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		K7EN45_HUMAN (75-163): 2.07e-43: 140: 100.00
+	Hs
		497827 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PIN4_HUMAN (38-160): 2.01e-29: 106: 33.33
+	Hs
		179126 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PINL_HUMAN (1-63): 6.34e-29: 104: 90.48