HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KCC2B (Q13554)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: CAMK2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043005 - neuron projection
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 666
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (1-569): 2.18e-140: 429: 23.76
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (2-579): 4.63e-139: 427: 24.96
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (1-552): 5.75e-138: 423: 24.49
+	Hs
		159141 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CSKP_HUMAN (10-308): 1.66e-81: 278: 46.73
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (1-569): 2.18e-140: 429: 23.76
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (1-569): 2.18e-140: 429: 23.76
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (1-552): 5.75e-138: 423: 24.49
+	Hs
		92372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E9PBG7_HUMAN (490-666): 6.9e-54: 194: 64.97
+	Hs
		496977 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2D_HUMAN (507-666): 1.24e-53: 193: 71.25
+	Hs
		497824 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KCC2A_HUMAN (493-663): 1.13e-50: 184: 61.40
+	Rn
		439487 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2B_RAT (436-666): 3.22e-58: 207: 60.52
+	Rn
		94121 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2B_RAT (436-666): 3.22e-58: 207: 60.52
+	Rn
		514946 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2G_RAT (490-666): 1.46e-57: 204: 72.88
+	Rn
		94132 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2G_RAT (490-666): 1.46e-57: 204: 72.88
+	Mm
		498111 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		KCC2G_MOUSE (469-666): 2.29e-58: 207: 65.15
+	Rn
		506692 TAU_RAT (1-758): 4.86e-75: 260: 71.47		KCC2A_RAT (493-663): 1.7e-50: 184: 61.40
+	Rn
		94129 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		KCC2A_RAT (493-663): 1.7e-50: 184: 61.40
+	Mm
		592770 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		KCC2D_MOUSE (507-666): 1.24e-53: 193: 71.25
+	Rn
		506773 PCLO_RAT (3-721): 3.96e-10: 65.9: 8.48		KCC2A_RAT (493-663): 1.7e-50: 184: 61.40