HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	35063084, 26402096, 26269332
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015630 - microtubule cytoskeleton
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2472
+	Rn
		555250 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN1_RAT (1-2472): 0: 713: 98.58
+	Rn
		94140 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN1_RAT (1-2472): 0: 713: 98.58
+	Hs
		164558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Rn
		582039 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SPTN2_RAT (141-1939): 1e-65: 251: 20.44
+	Rn
		94264 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SPTN2_RAT (141-1939): 1e-65: 251: 20.44
+	Hs
		496865 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		497051 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		497586 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80
+	Hs
		496188 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211474 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		503287 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Dm
		54271 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9I8_DROME (1-736): 6.78e-29: 130: 17.12
+	Hs
		503257 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25