HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CKAP5 (Q14008)
Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)
Gene: CKAP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26496610, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008017 - microtubule binding GO:0046785 - microtubule polymerization
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2032
+	Hs
		497372 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		GCN1_HUMAN (11-1217): 6.4e-66: 251: 12.00
+	Hs
		254542 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CLAP2_HUMAN (1086-1611): 1.06e-43: 177: 13.65
+	Rn
		582030 TAU_RAT (1-758): 4.86e-75: 260: 71.47		CLAP2_RAT (1086-1611): 2.97e-42: 172: 13.10
+	Rn
		94256 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		CLAP2_RAT (1086-1611): 2.97e-42: 172: 13.10
+	Hs
		497394 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TNPO1_HUMAN (688-1450): 2.98e-20: 100: 8.99
+	Hs
		497241 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CLAP1_HUMAN (366-1077): 2e-13: 78.6: 8.85
+	Hs
		127171 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IPO5_HUMAN (14-503): 9.94e-12: 72.8: 11.37
+	Hs
		496391 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		2AAA_HUMAN (656-1045): 2.01e-10: 68: 13.11
+	Mm
		498064 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		2AAA_MOUSE (4-466): 8.55e-17: 88.6: 12.58
+	Dm
		734228 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		2AAA_DROME (679-1081): 1.84e-44: 173: 14.75
+	Hs
		654004 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		CLAP1_HUMAN (366-1077): 2e-13: 78.6: 8.85
+	Hs
		127176 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		IPO5_HUMAN (14-503): 9.94e-12: 72.8: 11.37
+	Hs
		297835 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		CLAP1_HUMAN (366-1077): 2e-13: 78.6: 8.85