HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: SEPT6 (Q14141)
Septin-6
Gene: SEPTIN6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015630 - microtubule cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 434
+	Hs
		497368 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Mm
		498157 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SEPT6_MOUSE (1-434): 0: 606: 96.08
+	Hs
		497668 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEP11_HUMAN (3-400): 0: 548: 83.92
+	Hs
		90135 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		D6RGI3_HUMAN (3-400): 0: 547: 83.92
+	Hs
		807 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		A0A087X142_HUMAN (1-427): 0: 543: 74.36
+	Hs
		497093 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT7_HUMAN (2-425): 0: 529: 38.94
+	Mm
		498090 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		SEPT8_MOUSE (1-427): 0: 566: 76.46
+	Rn
		582045 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SEPT7_RAT (2-425): 0: 537: 38.80
+	Rn
		94268 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SEPT7_RAT (2-425): 0: 537: 38.80
+	Hs
		198179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT4_HUMAN (22-363): 8.07e-168: 481: 38.89
+	Hs
		497495 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT5_HUMAN (22-363): 8.01e-164: 467: 40.06
+	Hs
		497039 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT2_HUMAN (16-348): 1.31e-159: 456: 39.77
+	Hs
		497746 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT9_HUMAN (9-323): 2.65e-152: 445: 39.94
+	Hs
		497740 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SEPT3_HUMAN (7-307): 1.89e-152: 437: 40.45
+	Hs
		152655 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		SEPT7_HUMAN (2-425): 0: 529: 38.94