HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 407
+	Hs
		91440 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		E7EQG2_HUMAN (1-360): 0: 551: 100.00
+	Hs
		496685 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		497386 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		496251 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		133854 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Mm
		498030 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX17_MOUSE (25-407): 6.02e-132: 395: 31.20
+	Mm
		498084 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BTS0_MOUSE (22-407): 5.62e-132: 393: 30.96
+	Mm
		496125 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		IF4A2_MOUSE (1-407): 2.49e-129: 380: 100.00
+	Hs
		757612 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Dm
		1367483 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		IF4A3_DROME (10-407): 5.4e-130: 381: 69.85