HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MELK (Q14680)
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
Gene: MELK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21985311
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 651
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (3-651): 0: 569: 27.97
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (3-651): 0: 535: 25.07
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (3-651): 1.44e-171: 509: 26.56
+	Hs
		497702 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK1_HUMAN (3-651): 8.9e-168: 501: 24.13
+	Hs
		496670 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK1_HUMAN (9-547): 1.29e-140: 430: 26.61
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (3-651): 0: 569: 27.97
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (3-651): 1.44e-171: 509: 26.56
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (3-651): 1.44e-171: 509: 26.56