HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12888622
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0044297 - cell body
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 479
+	Hs
		496654 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09
+	Hs
		496496 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP3_HUMAN (194-476): 5.9e-97: 295: 32.87
+	Hs
		496497 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP2_HUMAN (212-478): 3.31e-94: 294: 27.60
+	Hs
		496655 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP6_HUMAN (206-478): 6.38e-90: 277: 30.53
+	Hs
		496377 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASP1_HUMAN (192-478): 1.67e-85: 270: 22.33
+	Hs
		496414 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CASPE_HUMAN (258-476): 3.03e-64: 209: 29.46
+	Hs
		788201 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CASP3_HUMAN (194-476): 5.9e-97: 295: 32.87