HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 261
+	Hs
		282300 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67
+	Hs
		497000 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16
+	Hs
		497761 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65
+	Hs
		497821 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		497012 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		496239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		497507 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SH3G2_HUMAN (47-261): 5.88e-23: 98: 18.14
+	Hs
		497550 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PACN1_HUMAN (6-261): 2.88e-22: 96.9: 19.09
+	Hs
		496577 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CRIP1_HUMAN (3-54): 2.22e-22: 89.5: 46.15
+	Hs
		496619 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		CRIP2_HUMAN (1-54): 1.16e-17: 80.7: 42.59
+	Hs
		497542 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30
+	Rn
		582018 TAU_RAT (1-758): 4.86e-75: 260: 71.47		BAIP2_RAT (19-261): 3.69e-24: 102: 15.35
+	Rn
		94244 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		BAIP2_RAT (19-261): 3.69e-24: 102: 15.35
+	Rn
		582013 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SRC8_RAT (36-260): 3.53e-23: 99: 22.55
+	Rn
		94238 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SRC8_RAT (36-260): 3.53e-23: 99: 22.55
+	Mm
		498047 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		PACN1_MOUSE (7-261): 1.63e-24: 103: 19.48
+	Hs
		1056870 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		STAC2_HUMAN (12-261): 3.72e-22: 96.5: 13.10
+	Rn
		193638 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SH3G1_RAT (48-261): 1.99e-23: 99.2: 16.97
+	Rn
		192354 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SH3G2_RAT (47-261): 8.45e-23: 97.2: 16.74
+	Rn
		192356 SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10		SH3G3_RAT (47-261): 1.28e-21: 94.2: 16.06