HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: IF4H (Q15056)
Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)
Gene: EIF4H

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 248
+	Hs
		496322 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		IF4B_HUMAN (33-208): 3.57e-31: 122: 32.78
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (33-237): 3.05e-27: 111: 15.46
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (33-219): 4.09e-24: 102: 13.54
+	Hs
		497020 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV3_HUMAN (42-122): 1.72e-23: 99: 25.30
+	Hs
		496346 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV4_HUMAN (35-123): 2.27e-22: 96.3: 25.28
+	Hs
		497019 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		RBM39_HUMAN (21-248): 5.04e-22: 96.3: 13.10
+	Hs
		496405 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TIA1_HUMAN (10-219): 1.78e-15: 76.7: 12.26
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (33-237): 3.23e-27: 111: 15.46
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (33-237): 3.23e-27: 111: 15.46
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (43-243): 4.31e-23: 99.4: 13.16
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (35-123): 2.56e-22: 95.9: 25.28
+	Mm
		497953 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		TIA1_MOUSE (10-224): 2.42e-14: 73.6: 12.90
+	Hs
		1054314 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		RBM39_HUMAN (21-248): 5.04e-22: 96.3: 13.10
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (33-237): 3.05e-27: 111: 15.46