HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: PLCB4 (Q15147)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
Gene: PLCB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1175
+	Hs
		497635 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCB1_HUMAN (2-1175): 0: 937: 37.46
+	Dm
		632600 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PIP1_DROME (5-1168): 0: 965: 35.48
+	Hs
		496595 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCD1_HUMAN (6-817): 0: 717: 27.34
+	Hs
		496268 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58
+	Hs
		496239 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PLCG2_HUMAN (546-887): 1.17e-73: 270: 22.82
+	Hs
		580935 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58