HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 471
+	Rn
		582003 TAU_RAT (1-758): 4.86e-75: 260: 71.47		NONO_RAT (1-471): 5.33e-93: 291: 97.69
+	Rn
		94227 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		NONO_RAT (1-471): 5.33e-93: 291: 97.69
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42
+	Hs
		497352 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Hs
		496346 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV4_HUMAN (40-205): 3.53e-60: 203: 28.02
+	Hs
		496310 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (66-458): 2e-64: 221: 14.72
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (66-458): 2e-64: 221: 14.72
+	Hs
		497020 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV3_HUMAN (54-270): 2.36e-48: 171: 22.46
+	Hs
		497082 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (41-465): 9.98e-64: 219: 15.03
+	Mm
		498050 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ELAV4_MOUSE (40-205): 7.55e-60: 202: 28.02
+	Hs
		496937 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ELAV2_HUMAN (150-210): 9.69e-14: 74.5: 25.81
+	Hs
		613456 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89
+	Dm
		60227 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A4V364_DROME (6-420): 1.65e-54: 192: 18.65