HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MARE2 (Q15555)
Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)
Gene: MAPRE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008017 - microtubule binding GO:0015630 - microtubule cytoskeleton GO:0019901 - protein kinase binding GO:0031110 - regulation of microtubule polymerization or depolymerization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 327
+	Mm
		498096 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		MARE2_MOUSE (1-327): 3.68e-174: 487: 96.94
+	Hs
		497813 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARE3_HUMAN (44-327): 9.07e-140: 398: 58.33
+	Hs
		497080 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARE1_HUMAN (44-308): 8.82e-139: 395: 56.60
+	Hs
		654077 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARE3_HUMAN (44-327): 9.07e-140: 398: 58.33
+	Hs
		503305 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARE3_HUMAN (44-327): 9.07e-140: 398: 58.33
+	Hs
		503288 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARE1_HUMAN (44-308): 8.82e-139: 395: 56.60
+	Hs
		297830 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		MARE1_HUMAN (44-308): 8.82e-139: 395: 56.60