HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DPYL2 (Q16555)
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene: DPYSL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 572
+	Hs
		497005 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Hs
		497006 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DPYL3_HUMAN (1-571): 0: 744: 76.71
+	Hs
		147310 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Rn
		581948 TAU_RAT (1-758): 4.86e-75: 260: 71.47		DPYL2_RAT (1-572): 0: 768: 98.78
+	Rn
		94172 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		DPYL2_RAT (1-572): 0: 768: 98.78
+	Rn
		582008 TAU_RAT (1-758): 4.86e-75: 260: 71.47		DPYL1_RAT (1-572): 0: 751: 75.87
+	Rn
		94232 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		DPYL1_RAT (1-572): 0: 751: 75.87
+	Mm
		498057 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DPYL3_MOUSE (1-571): 0: 743: 76.18
+	Hs
		497508 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DPYL5_HUMAN (9-567): 0: 653: 51.34