HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MA7D1 (Q3KQU3)
MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)
Gene: MAP7D1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26269332, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0015630 - microtubule cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 841
+	Hs
		497011 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MAP7_HUMAN (93-739): 6.52e-47: 181: 33.33
+	Hs
		496871 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ANK2_HUMAN (3-836): 3.38e-42: 169: 10.92
+	Hs
		497474 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MA7D2_HUMAN (97-658): 1.82e-33: 140: 20.57
+	Hs
		653987 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MA7D1_HUMAN (1-841): 4.12e-86: 294: 100.00
+	Rn
		562615 TAU_RAT (1-758): 4.86e-75: 260: 71.47		NFH_RAT (110-839): 6.05e-36: 149: 11.69
+	Rn
		94083 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		F1LRZ7_RAT (120-839): 5.35e-36: 149: 13.36
+	Hs
		497209 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		WDR87_HUMAN (111-808): 1.06e-09: 64.5: 9.96
+	Hs
		497357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TITIN_HUMAN (5-650): 3.29e-09: 63.4: 11.21
+	Hs
		496834 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MAP1A_HUMAN (35-816): 4.58e-09: 62.6: 10.63
+	Rn
		581937 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MAP1A_RAT (1-837): 7.33e-11: 68.4: 9.68
+	Rn
		94159 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MAP1A_RAT (1-837): 7.33e-11: 68.4: 9.68
+	Hs
		554259 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		MUC1_HUMAN (6-757): 2.27e-41: 166: 12.37
+	Hs
		1056827 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MDC1_HUMAN (4-839): 2.36e-33: 141: 9.01
+	Dm
		54595 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1Z9S6_DROME (32-826): 7.84e-36: 149: 10.05
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (19-746): 3.23e-19: 96.1: 8.73
+	Dm
		54348 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		Q9W053_DROME (606-769): 2.9e-10: 66.6: 21.47
+	Ce
		136802 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		UNC22_CAEEL (5-718): 8.67e-20: 97.6: 10.01
+	Hs
		1056876 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MICA3_HUMAN (177-761): 9.65e-11: 68: 13.95
+	Mm
		1351630 PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66		PCLO_MOUSE (50-839): 3.48e-27: 121: 9.49
+	Dm
		54892 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		A1ZA72_DROME (287-839): 1.14e-12: 74.6: 10.94