HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: FILA2 (Q5D862)
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)
Gene: FLG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26402096, 35063084
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 2391
+	Hs
		496312 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10A1_HUMAN (2-93): 2.13e-45: 161: 36.96
+	Hs
		380723 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S100B_HUMAN (1-92): 2.49e-44: 158: 36.96
+	Hs
		416341 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10A9_HUMAN (1-109): 6.76e-42: 151: 30.91
+	Hs
		496690 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10AA_HUMAN (2-89): 2.76e-39: 143: 34.09
+	Hs
		396671 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10A8_HUMAN (1-95): 8.99e-36: 133: 29.47
+	Hs
		416558 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10A6_HUMAN (4-90): 3.33e-27: 109: 31.03
+	Dm
		435986 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		CO4A1_DROME (1428-2389): 3.83e-87: 320: 10.55
+	Hs
		496287 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FILA_HUMAN (85-1558): 5.36e-18: 94: 17.52
+	Hs
		497487 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10AD_HUMAN (1-83): 5.04e-20: 89: 32.53
+	Hs
		497435 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		S10AG_HUMAN (2-97): 4.33e-19: 86.3: 28.87
+	Hs
		497264 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HORN_HUMAN (1590-2390): 3.13e-13: 78: 17.93
+	Hs
		152595 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		S10A2_HUMAN (2-91): 8.89e-40: 145: 32.22
+	Bt
		361268 TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00		S100B_BOVIN (1-92): 2.47e-44: 158: 38.04
+	Hs
		146221 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		ARI1A_HUMAN (169-1510): 1.82e-12: 75.5: 10.31
+	Dm
		1370237 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VMV5_DROME (2007-2376): 3.06e-24: 114: 10.11