HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.700

The method score is based on:

Property Details
Experiments 26268594, 24113872, 22303461
Identification Methods affinity chromatography technology, enzymatic study, protein kinase assay, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 10 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 758
Hs

1 2527
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024