HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CE170 (Q5SW79)
Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)
Gene: CEP170

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	36634849, 35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005874 - microtubule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 1584
+	Hs
		653991 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		CE170_HUMAN (1-1584): 0: 654: 100.00
+	Rn
		581937 TAU_RAT (1-758): 4.86e-75: 260: 71.47		MAP1A_RAT (91-1569): 9.15e-65: 246: 10.25
+	Rn
		94159 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		MAP1A_RAT (91-1569): 9.15e-65: 246: 10.25
+	Hs
		496529 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MAP1B_HUMAN (175-1557): 2.54e-45: 183: 9.56
+	Hs
		496834 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MAP1A_HUMAN (182-1393): 7.52e-37: 155: 10.27
+	Hs
		1056827 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MDC1_HUMAN (29-1563): 8.72e-84: 307: 10.03
+	Hs
		497357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68
+	Hs
		497818 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SRRM2_HUMAN (122-1517): 1.29e-18: 95.3: 9.74
+	Hs
		496871 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ANK2_HUMAN (318-1298): 5e-14: 80.2: 13.65
+	Mm
		88453 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		D3Z656_MOUSE (849-1383): 1.96e-12: 74.8: 13.42
+	Hs
		807793 PRG4_HUMAN (4-604): 5.21e-20: 97.8: 8.93		MAP1B_HUMAN (175-1557): 2.54e-45: 183: 9.56
+	Hs
		654031 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		C170L_HUMAN (1275-1584): 2.13e-29: 121: 93.23
+	Hs
		1303336 MUC4_HUMAN (14-748): 5.84e-22: 104: 10.95		MUC4_HUMAN (165-1560): 2.05e-33: 144: 9.47
+	Hs
		297837 K0754_HUMAN (5-450): 2.95e-22: 105: 11.86		C170L_HUMAN (1275-1584): 2.13e-29: 121: 93.23
+	Hs
		554259 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		MUC1_HUMAN (1087-1574): 2.68e-22: 106: 10.61
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (122-895): 8.05e-20: 99.4: 8.51
+	Hs
		1056876 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		MICA3_HUMAN (662-1403): 1.36e-13: 78.7: 12.99
+	Hs
		1263869 MUC16_HUMAN (1-752): 5.32e-13: 75.5: 7.82		C170L_HUMAN (1275-1584): 2.13e-29: 121: 93.23
+	Hs
		152667 KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55		KMT2C_HUMAN (378-1460): 4.45e-12: 73.7: 11.24
+	Ce
		136783 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		O17566_CAEEL (797-1346): 1.81e-12: 74.8: 11.69