HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TTBK1 (Q5TCY1)
Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)
Gene: TTBK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16923168
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007611 - learning or memory GO:0010629 - negative regulation of gene expression GO:0043025 - neuronal cell body
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1321
+	Hs
		254438 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROCK2_HUMAN (28-1017): 3.43e-125: 423: 12.54
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (7-752): 5.7e-130: 420: 14.29
+	Hs
		497766 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TNIK_HUMAN (34-914): 7.9e-124: 419: 12.92
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (4-692): 6.32e-120: 394: 16.49
+	Hs
		496548 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KC1D_HUMAN (26-448): 8.34e-116: 370: 30.70
+	Hs
		496547 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		KC1A_HUMAN (20-348): 1.94e-115: 366: 31.55
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (7-752): 5.7e-130: 420: 14.29
+	Hs
		1356429 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		TNIK_HUMAN (34-914): 7.9e-124: 419: 12.92
+	Rn
		987567 MAP4_RAT (60-757): 1.97e-10: 66.6: 8.17		KC1D_RAT (26-448): 2.29e-121: 385: 30.47