HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: BRSK2 (Q8IWQ3)
Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)
Gene: BRSK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21985311
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 736
+	Hs
		497338 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		BRSK1_HUMAN (16-711): 4.13e-167: 502: 68.86
+	Hs
		496358 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK3_HUMAN (7-678): 1.4e-163: 492: 25.76
+	Hs
		497224 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK2_HUMAN (4-678): 5.19e-158: 478: 25.58
+	Mm
		592769 MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89		BRSK2_MOUSE (1-736): 0: 638: 97.69
+	Hs
		497702 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK1_HUMAN (8-678): 1.08e-148: 455: 24.37
+	Hs
		497452 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MARK4_HUMAN (7-686): 2.77e-143: 439: 25.58
+	Hs
		496670 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK1_HUMAN (3-508): 8.58e-141: 434: 35.04
+	Hs
		503266 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK3_HUMAN (7-678): 1.4e-163: 492: 25.76
+	Hs
		497840 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		SIK3_HUMAN (16-353): 1.45e-78: 276: 43.49
+	Hs
		654032 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		MARK4_HUMAN (7-686): 2.77e-143: 439: 25.58
+	Hs
		503298 MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55		MARK4_HUMAN (7-686): 2.77e-143: 439: 25.58