HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 591
+	Hs
		497262 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HOME1_HUMAN (1-285): 2.84e-39: 149: 15.64
+	Hs
		497766 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TNIK_HUMAN (129-587): 5.09e-30: 128: 17.86
+	Hs
		159861 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HGS_HUMAN (90-385): 6.31e-28: 120: 22.22
+	Hs
		497357 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TITIN_HUMAN (81-495): 1.61e-25: 114: 11.06
+	Hs
		496999 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EIF3A_HUMAN (89-278): 2e-23: 107: 21.15
+	Mm
		498172 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HOME1_MOUSE (1-285): 2.08e-35: 138: 16.62
+	Rn
		582007 TAU_RAT (1-758): 4.86e-75: 260: 71.47		SYNJ1_RAT (243-580): 7.63e-09: 61: 14.33
+	Rn
		94231 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		SYNJ1_RAT (243-580): 7.63e-09: 61: 14.33
+	Mm
		88453 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		D3Z656_MOUSE (243-569): 1.22e-09: 63.7: 13.35
+	Dm
		54321 A1Z9J3_DROME (14-746): 5.58e-33: 139: 11.47		HRS_DROME (174-380): 6.01e-25: 111: 24.66
+	Mm
		1207212 NCOA6_MOUSE (23-739): 1.31e-24: 112: 9.76		KMT2C_MOUSE (109-562): 5e-26: 116: 12.50
+	Hs
		1356429 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		TNIK_HUMAN (129-587): 5.09e-30: 128: 17.86
+	Hs
		203228 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Dm
		113976 M9PB30_DROME (69-755): 2.38e-24: 112: 8.39		M9PB30_DROME (261-528): 1.31e-13: 76.8: 11.72
+	Hs
		203214 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18