HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DDX1 (Q92499)
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
Gene: DDX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 1 others more... GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 740
+	Hs
		133854 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX3X_HUMAN (1-380): 2.46e-40: 159: 13.47
+	Hs
		497386 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX17_HUMAN (1-381): 4.07e-36: 147: 12.21
+	Hs
		496251 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DDX5_HUMAN (1-381): 2.38e-34: 141: 11.96
+	Mm
		498056 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX3Y_MOUSE (1-380): 5.11e-39: 155: 13.22
+	Mm
		498030 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DDX17_MOUSE (1-381): 4.81e-36: 146: 12.21
+	Mm
		498084 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q8BTS0_MOUSE (1-381): 2.38e-34: 141: 11.96
+	Hs
		757612 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		IF4A3_HUMAN (3-72): 3.92e-11: 67.8: 30.00
+	Dm
		1367483 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		IF4A3_DROME (3-72): 1.44e-12: 72: 34.29