HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HS105 (Q92598)
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)
Gene: HSPH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26402096, 35063084
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005874 - microtubule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 858
+	Hs
		320800 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS74L_HUMAN (1-858): 0: 953: 57.46
+	Mm
		498049 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS105_MOUSE (1-858): 0: 984: 93.36
+	Hs
		496426 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Mm
		497946 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS74L_MOUSE (1-856): 0: 943: 56.31
+	Rn
		291980 TAU_RAT (1-758): 4.86e-75: 260: 71.47		HSP74_RAT (1-858): 0: 914: 61.28
+	Rn
		94108 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		HSP74_RAT (1-858): 0: 914: 61.28
+	Mm
		498021 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q3U2G2_MOUSE (1-858): 0: 910: 61.86
+	Hs
		554275 MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Dm
		1370298 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		Q9VUC1_DROME (1-844): 0: 821: 42.13
+	Hs
		497878 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HYOU1_HUMAN (1-839): 2.83e-81: 284: 27.41
+	Hs
		496165 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		483743 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS71A_HUMAN (586-707): 8.57e-31: 131: 21.14
+	Hs
		496425 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HS71L_HUMAN (586-716): 7.63e-31: 131: 19.70
+	Hs
		654083 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		HYOU1_HUMAN (1-839): 2.83e-81: 284: 27.41
+	Hs
		496242 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HSP76_HUMAN (604-707): 8.59e-27: 118: 22.86
+	Mm
		497918 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS71L_MOUSE (586-716): 1e-31: 134: 18.94
+	Mm
		497989 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HSP7C_MOUSE (489-709): 5.46e-32: 134: 11.26
+	Mm
		498048 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		HS71A_MOUSE (586-707): 1.61e-24: 111: 21.14
+	Dm
		220788 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		O46067_DROME (2-844): 1.56e-77: 272: 27.86
+	Hs
		503487 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26